Dan Goodman's prediction and politics journal.

Wednesday, June 02, 2004

Wednesday June 2, 2004. To Pillsbury House, where I did data entry for the Commmunity Barter Network and Pillsbury House's volunteer program.

After that, I went to Uncle Hugo's sf bookstore and Uncle Edgar's mystery bookstore.

"Jane Haddam is in a box on the floor" -- sign in the used section of Uncle Edgar's. In a mystery, there really would have been a mystery writer in a box on the floor.

On my way to Steeple People thrift store, this came into my head: "His father had been my mother, and his mother had been my father."

I have some idea what triggered it. I'd been looking out the bus window; decided that a bike rider was definitely female, the essential clue being wide hips. Then my thoughts drifted to usually being able to tell whether a woman had formerly been a man, because current sex-change technology isn't up to reshaping the pelvis (and the rest of the skeleton.)

Bought stuff at Steeple People. Headed for the Wedge co-op, across Lyndale Avenue. On the way, the next line came into my head: "And none of us really liked each other."

***Mail: Einblatt (Mnstf newsletter).
Penzys catalog, with a plug for Raspberry Enlightenment.
A guide to summer outdoor music in the Twin Cities area.
Writing: Daily exercise -- I decided those two lines which had come into my head would count for that.

"Well Met, Well Met, My Old True Love" -- A bit more done, which should make part of the ending more plausible.
Release of methane from a volcanic basin as a mechanism for initial Eocene global warming

I don't understand this one:
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

And the abstract doesn't help much:

In eukaryotic cells, messenger RNAs harbouring premature termination codons (PTCs) are rapidly degraded by a conserved post-transcriptional mechanism referred to as nonsense-mediated mRNA decay (NMD), which prevents the synthesis of truncated proteins that could be deleterious for the cell. Studies in yeast and mammals indicate that degradation by means of this pathway can occur from both the 5' end of the message (involving decapping and 5'-to-3' exonucleolytic digestion by XRN1) or the 3' end (through accelerated deadenylation and exosome-mediated 3'-to-5' decay). Here we show that, contrary to expectation, degradation of PTC-containing messages in Drosophila is initiated by endonucleolytic cleavage(s) in the vicinity of the nonsense codon. The resulting 5' fragment is rapidly degraded by exonucleolytic digestion by the exosome, whereas the 3' fragment is degraded by XRN1. This decay route is shown for several PTC-containing reporters, as well as an endogenous mRNA that is naturally regulated by NMD. We conclude that, despite conservation in the NMD machinery, PTC-containing transcripts are degraded in Drosophila by a mechanism that differs considerably from those described in yeast and mammals.
From Midwest Mountaineering's e-newsletter:
Buzz off clothing from Exoffico. It is finally here! Clothing that is treated to repel bugs. It has no smell, but bugs hate it. The treatment is supposed to last for over 25 washings. This would be great for fisherman who don't want DEET on their hands, people traveling to mosquito-infested areas of the world, or anyone living in Minnesota!

The Sterling climbing rope company is now making shoelaces...I know it may seem like a minor thing but these are really great laces. Built by people who make really great climbing ropes. Give you [sic] boots new life with some great new laces!
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